Technology Resources About Contact
Brilliant’s technology is designed to stimulate multiple brain sites rather than a single fixed target for next-generation TMS.
Smaller, proprietary Angle-Tuned coils may improve both depth and resolution. Clinics may reach relevant brain circuits focusing more precisely on intended targets.
Brilliant is creating systems with the potential to better match distributed neural circuits involved in depression and other neuropsychiatric conditions.
Improving coil and stimulation architecture, Brilliant is building a technology platform to support future therapies—addiction, smoking cessation, and other mental disorders.
Today’s TMS (1) therapies have proven that non-invasive magnetic stimulation can help patients with treatment-resistant depression, but current systems are still limited by single-site targeting, variable protocols, and restricted depth and focality. Brilliant Neurotechnologies is developing next-generation TMS designed to stimulate multiple brain sites, support improved treatment protocols, and deliver better depth and resolution for more precise engagement of depression-related neural circuits. By advancing the technology platform itself, Brilliant aims to improve outcomes for depression patients while creating a path toward new TMS-based therapies for conditions such as addiction and other neuropsychiatric disorders.Technology.
Transcranial Magnetic Stimulation, or TMS, uses rapidly changing magnetic fields to non-invasively induce small electrical currents in targeted brain regions. In depression therapy, TMS is most commonly directed at prefrontal brain circuits involved in mood regulation, with repeated sessions intended to shift neural activity over time. Current clinical systems have shown meaningful benefit for patients who have not responded adequately to medication, but treatment response can vary because the brain networks involved in depression are complex and patient-specific.
Brilliant Neurotechnologies is building on this foundation with next-generation coil and stimulation designs intended to improve how magnetic energy is delivered, targeted, and shaped in the brain. The company’s work on coil size reduction along with depth and resolution improvements is based on the 10+ years of research of Dr. Fow-Sen Choa at University of Maryland, Baltimore County (UMBC).
Smaller, proprietary Angle-Tuned (AT) coils are smaller and may support multi-site stimulation at greater depth and resolution.
Why multi-site stimulation, depth, and resolution may improve outcomes. Based on current TMS research, one reason outcomes can improve is that depression is increasingly understood as a network-level disorder rather than a problem in one isolated brain spot. Multi-site stimulation can allow treatment to engage more than one node in the mood-regulation network, potentially enabling more personalized protocols and better alignment with each patient’s neural circuitry. Improved depth allows treatments to reach clinically important circuits that are not well engaged by conventional surface-focused coils, while better resolution may help concentrate stimulation on intended targets and reduce spillover into surrounding tissue. Together, deeper reach and higher spatial precision could support stronger, more consistent modulation of depression-related pathways while opening a path to new protocols for addiction and other neuropsychiatric conditions, e.g. smoking cessation.
Multi-site stimulation may engage more nodes in neural networks